Düsseldorf, Germany July 18th, 2016.
ImmunoQure AG, a German biotechnology company focused on the development of autoantibodies as therapeutics to treat common human diseases today announced the publication of data in the leading scientific journal Cell, demonstrating that such therapeutics can limit a variety of common human diseases. ImmunoQure’s focus is the identification and development of antibodies derived from an ultra rare patient population with an autoimmune disorder called autoimmune polyendocrine syndrome type 1 (APS1 or APECED).
APS1/APECED is caused by monogenic defect in the autoimmune regulator gene (AIRE) that leads to a catastrophic destruction in central tolerance, characterized by the escape of naïve T cells targeting self-proteins from negative thymic selection. These auto-reactive T cells enable B cells to develop and subsequently generate highly matured self-reactive antibodies.